Slowing Down to Manage High Reactivity and an ISR** ---- an Integrated Stress Response

Conjecture

• Part of this is really not only giving ourselves permission to do this --- but others as well.
  • But we do need to get our own OXYGEN MASK ON.

 

• Right now managing having MORE REACTIVE CELLS and HYPER-CONNECTED BRAINS is pretty difficult and complicated.
  • I don't think that is always going to be the case.

Neuro-Diversity and a Ramped Up Stress Response

Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction (2017)

Affliation

• Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
  

The amygdala integrates and processes incoming information pertinent to reward and to emotions such as fear and anxiety that promote survival by warning of potential danger.

Basolateral amygdala (BLA) communicates bi-directionally with brain regions affecting cognition, motivation and stress responses including prefrontal cortex, hippocampus, nucleus accumbens and hindbrain regions that trigger norepinephrine-mediated stress responses.

Disruption of intrinsic amygdala and BLA regulatory neurocircuits is often caused by dysfunctional neuroplasticity frequently due to molecular alterations in local GABAergic circuits and principal glutamatergic output neurons.

Changes in local regulation of BLA (Basolateral Amygdala) excitability underlie behavioral disturbances characteristic of disorders including post-traumatic stress syndrome (PTSD), autism, attention-deficit hyperactivity disorder (ADHD) and stress-induced relapse to drug use.

In this Review, we discuss molecular mechanisms and neural circuits that regulate physiological and stress-induced dysfunction of BLA/amygdala and its principal output neurons.

We consider effects of stress on motivated behaviors that depend on BLA; these include drug taking and drug seeking, with emphasis on nicotine-dependent behaviors.

Throughout, we take a translational approach by integrating decades of addiction research on animal models and human trials.

We show that changes in BLA function identified in animal addiction models illuminate human brain imaging and behavioral studies by more precisely delineating BLA mechanisms.

In summary, BLA is required to promote responding for natural reward and respond to second-order drug-conditioned cues; reinstate cue-dependent drug seeking; express stress-enhanced reacquisition of nicotine intake; and drive anxiety and fear.

University of Michigan School of Medicine
Bipolar Disorder associated with MORE REACTIVE CELLS.

PBS Great Performances
Schumann believed to have Bipolar Disorder

University of Virginia School of Medicine
Immune System may have a large role in Social Behavior

Autism from the Inside

TRAUMA & CONSENT

This does need to be considered in personal relationships.

This is also complicated when we're talking about EMPLOYMENT and PUBLIC POLICY.

And Neuro-Diverse --- Highly Reactive People --- are often represented throughout our Economic & Political Spectrums.