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Translational medicine in Glial protection

12/31/2024

Val's Take/Conjecture

In 2013, the National Institute of Mental Health (NIMH) proclaimed the DSM 5 "lacked validity" because it was based on clusters of symptoms and not the underlying biology.
The American Psychiatric Association said, "Well, what is your alternative?"
NIMH said, "We'll get back to you on that."
Since then the basic research has exploded.
On the other hand, the Translational Research and Medicine perhaps predictably has lagged behind.
That is slowly starting to change.
Part of that is recognizing the glial protective aspects of current medications (which may not work for everyone) and
Pursuing Novel Therapeutic Medications and Approaches.

Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice (2024)

The Janus face of antipsychotics in glial cells: Focus on glioprotection (2023).

"[C]onverging lines of evidence indicate that psychiatric disorders are commonly associated with the triad

neuroinflammation,
oxidative stress, and
excitotoxicity, and

that glial cells may contribute to the gliotoxicity process.

"Conversely, glioprotective molecules attenuate glial damage by generating specific responses that can protect glial cells themselves and/or neurons, resulting in improved central nervous system (CNS) functioning.

"In this regard, resveratrol is well-recognized as a glioprotective molecule, including in clinical studies of schizophrenia and autism."
"[C]onverging lines of evidence indicate that psychiatric disorders are commonly associated with the triad

neuroinflammation,
oxidative stress, and
excitotoxicity, and

that glial cells may contribute to the gliotoxicity process.

"Conversely, glioprotective molecules attenuate glial damage by generating specific responses that can protect glial cells themselves and/or neurons, resulting in improved central nervous system (CNS) functioning.

"In this regard, resveratrol is well-recognized as a glioprotective molecule, including in clinical studies of schizophrenia and autism." "[C]onverging lines of evidence indicate that psychiatric disorders are commonly associated with the triad

neuroinflammation,
oxidative stress, and
excitotoxicity, and

Microglia and cognitive impairment in schizophrenia: translating scientific progress into novel therapeutic interventions (2023).

Suicide in bipolar disorder patients is associated with hippocampal microglia activation and reduction of lymphocytes-activation gene 3 (LAG3) microglial checkpoint expression (2023).

Role of Microglial Modulation in Therapies for Perinatal Brain Injuries Leading to Neurodevelopmental Disorders (2024).

Editorial

Special Issue "Microglia Heterogeneity and Its Relevance for Translational Research" (2021)

Val's Take: One of the things that happened with NIMH and Researchers around the world: They started saying these neuro-developmental & psychiatric disorders are "BLURRED."

Since that time, it has become more obvious that there are common mechanisms in a range of CHRONIC DISEASE --- the actual "dysregulation" may be different --- but those new understandings are multiplying to benefit a range of illnesses.

Lead and Psychiatric Disorders

12/16/2024

Val's Take/Conjecture

"Lead" in gasoline in the 20th Century is currently being identified as a "CAUSE" of poor mental health.
At least at one point, Lead was identified with the Fall of the Roman Empire.
- I think most historians would identify a range of factors --- but "Lead" may come back in popularity as a factor with regard to the fall of ancient Rome.

To me when people say --- "Hey, I think this is a factor in mental health" ---- I think they are generally right.

To me, this is really about Developmental and After Acquired INFLAMMATION --- so it can be a lot of things and a lot of combinations of things.

There's realization in Medicine and Psychiatry for the need for INDIVIDUALIZED PRECISION MEDICINE.

20th Century Lead Exposure Damaged American Mental Health
Dec. 4, 2024

IT IS NOT JUST LEAD

There are any number of environmental toxins that can impair mental health.

The exposomeThe role of the exposome is to understand how the totality of an individual's exposures throughout the lifetime can impact human health.

Translational Medicine Friday

We're riffing off NPR's Science Friday to create Translational Medicine Friday.

We'll be collecting Research Article recommendations for Clinicians with regard to Cognitive Disability.

There is much in the RESEARCH JOURNALS and we'll just be SKIMMING THE SURFACE.

The POINT is to INCREASE FUNDING for TRANSLATIONAL RESEARCH at the Federal Level for the National Institutes of Health, the Centers for Disease Control, the Nation's Research & Teaching Hospitals and possible collaborations with Medicare and Medicaid providers.

Translational Medicine Friday

Translational medicine in Glial protection

Lead and Psychiatric Disorders

Translational Medicine Friday

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