Blog Archives

2025 Research: Neo-Natal Inflammation, Microglia, and Investigation of New Treatments

2/7/2025

2025 is bringing a continued focus on:

Neo-Natal Inflammation
Microglia (the Brain's Innate Immune Cells), and
More Investigation of New Treatments

Remimazolam attenuates lipopolysaccharide-induced neuroinflammation and cognitive dysfunction (2025)

Ginsenoside reprogramming microglia through the FGF/FGFR1 inhibits post traumatic stress disorder (2025)

Neonatal inflammation impairs developmentally-associated microglia and promotes a highly reactive microglial subset (2025)

Chronic Fatigue Syndrome & Neuro-developmental / Psychiatric Disorders

2/6/2025

Val's Take: IT TAKES A LOT OF TIME AND ENERGY to UNDERSTAND THESE DISORDERS, especially if they have not been easily resolved with current understandings.

What's left is pretty darn complicated --- Health Disorders such as:

Neuro-Developmental and Psychiatric Disorders
ME/CFS
Cancer
Autoimmune Diseases
Neuro-Degenerative Disorders
Neuro-Immune Disorders
Etc.

Most "Neuro-Developmental" and "Psychiatric" diagnoses at this point are conceptualized as NEURO-DEVELOPMENTAL, MULTI-SYSTEM DISORDERS in the Research.

How many People know that?
How many Clinicians know that?
How many Policymakers?

University of Michigan School of Medicine
Dr. Melvin McInnis

The Cells of People with Bipolar Disorder are Developmentally Different (2017)

Columbia Public Health
Dr. Mady Hornig

Scientists Discover Robust Evidence That Chronic Fatigue Syndrome (ME/CFS) Is a Biological Illness (2015)

Broken Battery

ME/CFS -- The Greatest Medical Scandal of the 21st Century (2024)

Many people with Neuro-Developmental & Psychiatric Disorders have issues with Burnout, Melt Downs & Shut Downs. BIO-ENERGETICS is turning out to be a big issue in Neuro-Developmental & Psychiatric Disorders.

In fact, some type of Mitochondrial Dysfunction and Fatigue is associated with many diseases and disorders.

A lot of people in the Homeless Population get tagged with being "LAZY" or "UNMOTIVATED," and I think what is going on is much more complicated.

Astrocytes in Depression and a complicated biological universe for criminal justice

2/5/2025

Various types of GLIAL CELLS in both the Central Nervous System (CNS) and the Peripheral Nervous System (PNS) seem critical in Neuro-Developmental Disorders, Psychiatric Disorders, Neuro-Degenerative Disorders as well as other Diseases and Disorders.

This is exceedingly complicated in 2025.

What happens if we have a Criminal Justice System that is unable to deal honestly and effectively with this COMPLEXITY?

Well, you might live in the most incarcerated country in the world that still has significant safety problems.

NeuroLingo

Liam Anuj O'Leary
McGill University (Canada)
McGill Group for Suicide Studies

Fewer astrocytes in depression

Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number (2025)

Widespread Decrease of Cerebral Vimentin-Immunoreactive Astrocytes in Depressed Suicides (2021)

Forward>>

Translational Medicine Friday

We're riffing off NPR's Science Friday to create Translational Medicine Friday.

We'll be collecting Research Article recommendations for Clinicians with regard to Cognitive Disability.

There is much in the RESEARCH JOURNALS and we'll just be SKIMMING THE SURFACE.

The POINT is to INCREASE FUNDING for TRANSLATIONAL RESEARCH at the Federal Level for the National Institutes of Health, the Centers for Disease Control, the Nation's Research & Teaching Hospitals and possible collaborations with Medicare and Medicaid providers.

Translational Medicine Friday

2025 Research: Neo-Natal Inflammation, Microglia, and Investigation of New Treatments

Chronic Fatigue Syndrome & Neuro-developmental / Psychiatric Disorders

Astrocytes in Depression and a complicated biological universe for criminal justice

Translational Medicine Friday

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