​Val's Take/Conjecture

• Maternal Immune Activation was probably fairly common in Ancient Times.
• In Modern Times, it has been fairly common-- affecting approximately 1/5 to a 1/4 of the population.
• But it is only recently that we are starting to get a more complete BIOLOGICAL NARRATIVE.

I think disruptions in biological systems as a result of Maternal Immune Activation may have inspired Aristotle and others to focus on "Balance" and "Homeostasis/"

​Adult microglial TGFβ1 is required for microglia homeostasis via an autocrine mechanism to maintain cognitive function in mice (2024)

​Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant behavior phenotypes via arginase 1 in the dentate gyrus (2020)

Val's Take/Conjecture

A lot of neuro-diverse people --- talk a lot about the "SUPER POWERS" of various forms of neuro-diversity.

It is extremely important to identify those "SUPER POWERS."

There is a crying, desperate need to address the DISCONNECT between what people are processing and what it actually takes to do that.

Further, people on the neuro-diverse/psychiatric continuum are generally dealing with "ENERGY ISSUES."

In general, most people think of PSYCHOSIS as "mental health" or poor mental health --- and if someone is suicidal --- that seems like mental health.

​Beyond that I think most people would be hard pressed to recognize more subtle issues that are desperately important.

A lot of neuro-diverse people talk about BURN-OUTS and MELT-DOWNS and at least in part these are ENERGY issues.

"Brain Energy" has been a big book for Dr. Chris Palmer.

I think there is a lot to understand --- and appreciate and further develop and revise.

But at the end of the day ---
​
THIS IS BIG!  Brain Energy is an essential concept to neuro-developmental disorders and psychiatric disorders.

Transdiagnostic Patterns of Sensory Processing in Autism and ADHD. (2024)

To make things more challenging --- this is when we generally talk about our "SUPER POWERS" and how we are so creative, innovative, and intelligent --- even as the latest BURN-OUT or MELT-DOWN is smoldering in the background.

Dealing with these energy issues is one of the keys to preventing a worsening of symptoms.

Many neuro-diverse people are coming with significant anxiety as the result of Maternal Immune Activation and any environmental contributors.

A source of HUGE ANXIETY for Neuro-Diverse people is not being able to manage their time in an atypical way in order to avoid BURN-OUTS and MELT-DOWNS.

Further, those Neuro-Diverse "SUPER POWERS" should be leveraged for mutual benefit.

Val's Take/Conjecture

• "Migraines" need professional treatment.
• Neuro-Developmental and Psychiatric Disorders are PHYSICAL ISSUES.  That is much more apparent in 2024 than it has been in the past.

Psychiatric comorbidities of migraine (2024)

Handbook of Clinical Neurology

Migraine is commonly comorbid with psychiatric conditions, particularly major depressive disorder, anxiety disorders, and sleep disorders.

The presence of psychiatric disorders can make diagnosis and treatment more challenging. 

Autism from the Inside
Autism/Chronic Illness --- Is There An Overlap

​ADHD and Migraine: What‘s the Link? - Psych Central Mar 28, 2022 · Migraine with aura, also called “classic migraine,” has a particularly strong link with ADHD.