Blog Archives

Immune dysregulation in Anti-Social Personality Disorder, Aggression and Substance use

2/16/2025

Val's Take

It would be great if the Colorado Mental Health Profession generally and those working in Forensics 
- would STEP UP and substantively address the historical problems of insufficient mental health knowledge in the CRIMINAL JUSTICE SYSTEM and the need to incorporate new understandings and remedy past mistakes of overloaded systems.

Transcriptional and epigenetic regulation of microglia in substance use disorders (2023)

Maternal immune activation and adolescent alcohol exposure increase alcohol drinking and disrupt cortical-striatal-hippocampal oscillations in adult offspring (2022)

Microglia in neuroimmunopharmacology and drug addiction (2024)

Aggression --- Humanity's Ultimate Double-Edged Sword

Hair Analysis, Psychological Analysis, the Criminal Law & the Ethical & Moral Imperative to Pull Back

Antisocial personality disorder: Failure to balance excitation/inhibition? (2025)

Article is meant among other things "to enhance societal awareness and reception of the neurobiological basis of antisocial behavior and ASPD [Anti-Social Personality Disorder]."

The neurobiology of antisocial personality disorder [APD] (2024)

Associations of the immune system in aggression traits and the role of microglia as mediators (2024)

Resveratrol prevents offspring's behavioral impairment associated with immunogenic stress during pregnancy (2025)

Academic Proposal that Anti-Social Personality Disorder is a Neuro-Developmental Disordeer

Justice & the Need for better outcomes in behavioral Health

2/8/2025

Val's Take

We need to get Clinicians and the Public more aware of critical research involving the Neuro-Developmental/Psychiatric Continuum of the last 10 years.
Developmental Issues occurring IN UTERO are not widely known --- even if they are widely discussed in the research.
Further, Dysregulation of the Brain's INNATE IMMUNE CELLS appear to have far-ranging effects across the lifespan.
We need to provide the SUPPORT necessary for Behavioral Health to be a competent profession.

No Good Deed Goes Unpunished

"No good deed goes unpunished" is a sardonic commentary on the frequency with which acts of kindness backfire on those who offer them.

In other words, those who help others are doomed to suffer as a result of their helpfulness.

No good deed goes unpunished, no bad one unrewarded. --- Walter Map, 12th Century

--- Wikipedia

"The Earth is not flat" -------------NEURO-DEVELOPMENTAL DIFFERENCES / DISABILITIES, "MENTAL ILLNESS," WORK AROUNDS & CRITICAL THINKING

Research is Everybody's Business

Gary Clark, Jr.
Bright Lights

You're gonna know my name by the end of the night --- MICROGLIA

Behavioral Health Outcomes Lag Behind Most Major Diseases Despite Higher Costs (2025)

[Information provided by YOUU Health on EIN Presswire]

The Eggshell Skull Rule and Environmental Toxins

2/7/2025

What are the implications of the "Eggshell Skull Rule" and the "Exposome" for Neuro-Diverse people with Maternal Immune Activation?

Val's Take/Conjecture

Maternal Immune Activation does seem to create idiosyncratic vulnerabilities, including types of immuno-compromised systems.

There are man-made toxins and natural toxins.

PESTICIDES

Immuno-compromised people are more vulnerable to Pesticides than people who are not immuno-compromised.
- Pesticides are also associated with increased risk of Parkinson's.
- Environmental Exposure to Pesticides and the Risk of Child Neurodevelopmental Disorders (2024)

MICROPLASTICS

Impacts of microplastics on immunity (2022)

Environmental Toxins & Mental Health

Previously we've conceptualized Neuro-Developmental, Psychiatric and Neuro-Degenerative Disorders as having to do with the Brain and Neurons.

More and more we are conceptualizing these disorders as NEURO-IMMUNE DISORDERS, and there are more components than that.

BUT the Immune System is a critical system --- and we can't understand these disorders without understanding the Immune Component.

THE EXPOSOME ACROSS THE LIFESPAN & TRANS-GENERATIONAL IMPLICATIONS

"The exposome concept refers to the totality of exposures from a variety of external and internal sources including chemical agents, biological agents, or radiation, from conception onward, over a complete lifetime.
"It encompasses also 'psychosocial components' including the impact of social relations and socio-economic position on health."

EGGSHELL SKULL RULE

The eggshell skull rule, also known as the thin skull rule, is a common law doctrine that makes a defendant liable for the plaintiff's unforeseeable and uncommon reactions to the defendant's negligent or intentional tort .

If the defendant commits a tort against the plaintiff without a complete defense , the defendant becomes liable for any injury that is magnified by the plaintiff's peculiar characteristics.

It is essential to emphasize that the eggshell skull doctrine does not entitle the plaintiff to compensation for an unrelated pre-existing injury.

A common example of this doctrine is that a person's skull was very thin due to the person’s own health condition, if the person gets into an accident, the other person who caused the accident will be liable for the actual damages , although the average person would not suffer the same serious injuries in the same accident as the person with the thin skull.

Late prenatal immune activation in mice induces transgenerational effects via the maternal and paternal lineages (2023)

Having a come to jesus with the budget hawks &the problem of dangerous defendants with some form of cognitive disability

2/6/2025

Val's Take

One of the things that happens frequently in Colorado State Government is the creation of a bureaucracy, or office, or navigator system in lieu of MUCH MORE EXPENSIVE:
- Housing or
- Secure Placements
- Etc.

Of course if there are people being stabbed in Downtown Denver --- these administrative fixes are not much of a bargain.

A big complicating factor is that Jails are generally financed by the COUNTY and Mental Institutes are financed by the STATE.
Counties around the country and in Colorado want people with "mental illness" out of their jails because it is a LARGE COST they don't want.

The IMD Rule & Administrative Enforcement of Disability Civil Rights Laws

The Stepping Up Initiative to get people with mental illness out of the jails has been around for awhile --- and there are many stakeholders but most prominent are the COUNTIES.

Denver has tackled the issue of Housing to an almost miraculous degree.

BUT not everyone is going to be able to go to SUPPORTIVE HOUSING initially and maybe even --- EVER given current treatments.

The State seems aware of the need to build out the CONTINUUM OF CARE but doesn't know where it will get the money.

Getting more FEDERAL FUNDING could help.

CMS' Failure to Cover Housing for Long Term Care & the IMD Rule: What they have in common is Discrimination

Martin Luther King Day 2025: Historian John Hope Franklin & the Great man theory of History

2/6/2025

Val's Take

Historian John Hope Franklin rejected the 19th Century's idea of the Great Man Theory of History for appreciating the influence of Marginalized Social Groups on the trajectory of history.

Racism & Mental Health

Social Stress, Equitable Estoppel & the Criminal Justice System

structural racism, bad diagnostics and Anti-Social Personality Disorder

Historian John Hope Franklin interview with National Museums Liverpool

"I am a trained historian therefore I am slow to provocation. On the other hand, I am involved with slavery not only as an historian but personally."

Transitional/ Translational Justice Monday

Immune dysregulation in Anti-Social Personality Disorder, Aggression and Substance use

Justice & the Need for better outcomes in behavioral Health

The Eggshell Skull Rule and Environmental Toxins

Having a come to jesus with the budget hawks &the problem of dangerous defendants with some form of cognitive disability

Martin Luther King Day 2025: Historian John Hope Franklin & the Great man theory of History

Archives

Categories

Transitional/ Translational Justice Monday

Immune dysregulation in Anti-Social Personality Disorder, Aggression and Substance use

Justice & the Need for better outcomes in behavioral Health

The Eggshell Skull Rule and Environmental Toxins

Having a come to jesus with the budget hawks &​the problem of dangerous defendants with some form of cognitive disability

Martin Luther King Day 2025: Historian John Hope Franklin & the Great man theory of History

Archives

Categories

Having a come to jesus with the budget hawks &the problem of dangerous defendants with some form of cognitive disability